Bioactive Small Molecules
Selleck Chemical LLC DIRECT RED 80 E2905-100MG
Direct Red 80 (Sirius Red) is a polyazo dye used principally in staining methods for collagen and amyloid Direct Red 80 does not release benzidine upon degradation and is safer than many traditional direct dyes
Selleck Chemical LLC GynostemmapentaphyllumExtract E3343-25MG
Gynostemma Pentaphyllum Extract isolated from the herb of Gynostemma pentaphyllum enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1 in C2C12 skeletal muscle
Selleck Chemical LLC Garcinia cambogia extract E2863-25MG
Garcinia cambogia extract has hypocholesterolemic effect and used for obesity treatment (-)-hydroxycitrate (HCA) the chief compound of standardized Garcinia cambogia extract is a competitive inhibitor of ATP-citrate-lyase
Ubpbio A potent and irreversible cysteine-modifying inhibitor of STING, CAS# 941987-60-6, > 98% purity
H-151 is a potent and irreversible inhibitor of stimulator of interferon genes (STING). It covalently modifies cysteine 91 of STING, which blocks STING palmitoylation and clustering, events essential for downstream TBK1 activation and type I interferon production during immune responses to pathogenic and self-DNA detection by the cGAS-STING pathway.
Cayman Chemical ANTIBODY PIK-293 10mg
A selective inhibitor of the PI3K catalytic subunit p110δ (IC50s = 0.24 µM)
Cayman Chemical ANTIBODY eCF506 25mg
An inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRα, and RET (IC50s = >100 µM for all); completely inhibits Src and FAK phosphorylation at 100 nM; inhibits proliferation of MCF-7 cells (EC50 = 9 nM); reduces levels of activated Src kinase in tumor tissue in an HCT116 mouse xenograft model at 50 mg/kg per day
Cayman Chemical Estetrolhydrate 5mg
An estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy; binds ERα with 4-fold higher affinity for over ERβ; exhibits estrogenic effects in bone, brain, vagina, and endometrium; acts as an estrogen antagonist in the presence of estradiol, preventing breast tumor growth
Cayman Chemical ANTIBODY CVT-10216 1mg
A selective, reversible inhibitor of ALDH2 (IC50 = 29 nM); reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects
Cayman Chemical ProstaglndIn I2sodIum salt 5mg
PGI2 is an unstable COX metabolite detected first in vascular endothelial cells.{502,443,933} It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM.{4375} PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1α in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.{5466}
Medchemexpress LLC HYOU1 Human HEK293 500ug
Recombinant human HYOU1 (hypoxia up-regulated protein 1) is supplied as a His-tagged protein expressed in HEK293 cells and provided as a lyophilized powder for research use. The preparation is characterized for endotoxin level and ATPase activity, and is formulated in PBS for reliable reconstitution and long-term storage.
- Recombinant human protein expressed in HEK293 cells for native-like glycosylation.
- His-tagged for convenient detection and purification applications.
- Lyophilized powder formulation for extended shelf life and easy shipping.
- Low endotoxin level (<1 EU/μg) suitable for sensitive assays.
- Characterized ATPase activity with reported specific activity for functional studies.
- Provides recommendations for reconstitution and storage to preserve activity.
Medchemexpress LLC LRP-12 Human HEK29 50ug
Recombinant human LRP-12 protein produced in HEK293 cells with a C-terminal His tag. The purified, glycosylated protein is supplied for research use and is available in multiple quantities, including a 50 μg format; the manufacturer provides the amino acid sequence and an indicated apparent molecular weight range.
- Recombinant human LRP-12 expressed in HEK293 cells.
- C-terminal hexahistidine tag for affinity purification.
- Glycosylated protein with apparent molecular weight ~60-85 kDa.
- Supplied as purified protein in multiple sizes, including 50 μg.
- Full amino acid sequence provided for validation and assay design.
- Suitable for biochemical assays, binding studies, and antibody validation.
Cayman Chemical ANTIBODY IcarItIn 5mg
A flavonoid that inhibits FASN, reducing IGF-1-induced activation of STAT3 in several melanoma cell lines
Cayman Chemical ANTIBODY BohemIn 5mg
A Cdk inhibitor (IC50s = 4.6, 8.3, and 2.7 µM for Cdk2/cyclin E, Cdk2/cyclin A, Cdk9/cyclin T1, respectively); suppresses tumor cell growth, inducing G1 and G2 phase cell cycle arrest
Cayman Chemical ANTIBODY LomustIn 100mg
A DNA alkylating agent; forms DNA interstrand crosslinks and strand breaks; reduces tumor volume in a melanoma mouse xenograft model at 4-16 mg/kg