Bioactive Small Molecules
Medchemexpress LLC Asperulosidic acid | 25368-11-0 | MFCD21333373 | 1 MG
Asperulosidic acid (ASPA) is a bioactive iridoid glycoside extracted from the herbs of Hedyotis diffusa Willd. It exhibits anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA's activities are linked to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators through the suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
- Bioactive iridoid glycoside
- Extracted from *Hedyotis diffusa Willd*
- Anti-tumor activity
- Anti-oxidant activity
- Anti-inflammatory activity
- Suppresses NF-κB and MAPK signaling pathways
- Down-regulates mRNA levels of TNF-α and IL-6 in LPS-induced RAW 264.7 cells
- Decreases IκB-α phosphorylation
- Reduces Erk1/2 phosphorylation
Apexbio Technology LLC LY2801653 1206799-15-6 5mg
LY2801653 (CAS 1206799-15-6) is an orally bioavailable small molecule inhibitor targeting the c-MET receptor tyrosine kinase with an IC50 of 2 nM c-MET also known as hepatocyte growth factor receptor (HGFR) mediates key cellular processes including proliferation survival and motility its dysregulation has been associated with tumor progression and metastasis LY2801653 acts as an ATP-competitive inhibitor of c-MET phosphorylation In vitro it fully inhibits HGF-induced cell scattering in DU-145 cells at concentrations from 0 01 to 10 M and shows greater antiproliferative effects in MET-expressing cell lines In vivo LY2801653 reduces apoptosis and angiogenesis in xenograft models supporting its utility in cancer research
Cayman Chemical Zosuquidar (hydrochloride), Purity: ≥98%, CAS: 167465-36-3, 5 mg
A modulator of P-gp (Ki = 59 nM); restores the sensitivity of P-gp-expressing cancer cells to vinblastine, doxorubicin, etoposide, and paclitaxel; enhances the distribution of P-gp substrates through the BBB into the brain
Medchemexpress LLC HY-W011100 50mg Medchemexpress, Cyclofenil CAS:2624-43-3 Purity:>98%
Medchemexpress, HY-W011100 50mg Cyclofenil CAS:2624-43-3 Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC DMT-dG(dmf) Phosphoramidite | 330628-04-1 | 98.8% | 824.90 | 10 G
DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that plays a crucial role in the preparation of oligonucleotides. This compound is strictly for research purposes and not intended for patient use.
- Phosphinamide monomer
- Supports oligonucleotide synthesis
- For research use only
- Targets DNA/RNA synthesis pathways
- Involved in cell cycle and DNA damage pathways
- Store at -20°C, protected from light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C (protect from light)
- Soluble in DMSO at 100 mg/mL
Cayman Chemical XL335, Purity: ≥98%, CAS: 629664-81-9, 5 mg
A potent and selective FXR agonist (EC50 = 4 nM in CV-1 cells transfected with human FXR); selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 μM; induces a 20-, 13-, and 2-fold increase in mRNA expression for IBABP, BSEP, and SHP, respectively, at a concentration of 1 μM; reduces plasma cholesterol and triglycerides and the area of pre-atherosclerotic lesions in LDLR-/- mice fed a Western diet; decreases hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis
Medchemexpress LLC HY-106048 25mg Medchemexpress, Bredinin aglycone CAS:56973-26-3 Purity:>98%
Medchemexpress, HY-106048 25mg Bredinin aglycone CAS:56973-26-3 Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Senecionine (senecionan-11,16-dione, 12-hydroxy-) | 130-01-8 | MFCD00221720 | 99.5% | 335.39 g/mol | C18H25NO5 | 10 MG
Senecionine is a pyrrolizidine alkaloid supplied as an analytical standard for research and analytical applications. The compound is provided as a solid and has been reported to decrease glutathione S-transferase activity and related enzymatic activities. Handle and store protected from light.
- Analytical standard for research and analytical applications.
- High purity: 99.5%.
- CAS number 130-01-8.
- Molecular formula C18H25NO5 and molecular weight 335.39 g/mol.
- Supplied as a 10 MG solid, white to off-white.
- Store protected from light; in solvent: -80°C (6 months), -20°C (1 month).
TARGETMOL CHEMICALS INC CEDIRANIB 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro also inhibits Flt1/4 (IC50 5 nM/≤3 nM) similar activity against PDGFR(beta) and c-Kit selective more for VEGFR than PDGFR-(alpha) (36-fold) CSF-1R (110-fold) and Flt3 (1000-fold) in HUVEC cells. purity: 99%
Cayman Chemical TC-E 5003, Purity: ≥98%, CAS: 17328-16-4, 50 mg
A PRMT1 inhibitor (IC50 = 1.5 µM); selective over CARM1/PRMT4 and SET7/9 methyltransferases (50s = 1.97 and 4.49 µM, respectively); decreases androgen-dependent gene transcription in vitro; eradicates P. berghei in mice
TARGETMOL CHEMICALS INC PIMECROLIMUS 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pimecrolimus (SDZ-ASM 981) a calcineurin inhibitor immunosuppressant binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. purity: 99%
Selleck Chemical LLC Navitoclax (ABT-263) 25mg 923564-51-6
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ? 0.5 nM, ?1 nM and ?1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical GSK256066, Purity: ≥98%, CAS: 801312-28-7, 1 mg
A potent PDE4 inhibitor (IC50s = 4.9, 3.2, 3.8, and 1.1 pM for PDE4A, PDE4B, PDE4C, and PDE4D, respectively); >380,000-fold selective for PDE4 over PDE1-3, -5, and -6 and >2,500-fold selective over PDE7; inhibits LPS-induced TNF-α production in human peripheral blood monocytes (IC50 = 0.01 nM) and human whole blood (IC50 = 126 pM); intratracheal adminstration inhibits LPS-induced pulmonary neutrophilia in rats (ED50 = 1.1 µg/kg); inhibits ovalbumin-induced pulmonary eosinophilia in rats (ED50 = 0.4 µg/kg) and LPS-induced pulmonary neutrophilia in ferrets (ED50 = 18 µg/kg)
Medchemexpress LLC P-Selectin Human B 20ug | 20ug
P-selectin is a Ca(2 )-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes promoting the interaction between activated endothelial cells or platelets and leukocytes interaction This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation P-Selectin Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived P-Selectin protein expressed by HEK293 with C-Avi C-His labeled tag
Cayman Chemical TM5275, Purity: ≥95%, CAS: 1103926-82-4, 25 mg
A PAI-1 inhibitor (IC50 = 6.95 µM); inhibits formation of a complex consisting of tPA, PAI-1, and GFP on VECsin vitro, prolonging the time that tPA is retained on VECs; decreases blood clot weight in a rat model of arteriovenous shunt thrombosis when used at doses of 10 and 50 mg/kg; increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model in rats when used at doses of 1 and 3 mg/kg; increases the time to primary occlusion in a cynomolgus monkey model of photochemical-induced arterial thrombosis when used at a dose of 10 mg/kg; does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time